Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
A review of the broad sweep of organ-chip research in the cancer research in the UK, and the network of researchers and companies being developed, published in the journal Cancers in 2023 and available here.
Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
A study combining transcriptomics (RNAseq) and computational modelling (CFD) to investigated the role played by aging and TGF-β in osteocyte mechanosensing, published in the Proceedings of the National Academy of Sciences (PNAS) in 2021 and available here. Abstract Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the mechanisms … Continue reading Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
An organ-on-a-chip model of the how mechanical stimulation of osteocytes affects the phenotype of breast and prostate cancer cells, published in the journal Cancers 2021 and available here. Abstract Breast and prostate cancers preferentially metastasise to bone tissue, with metastatic lesions forming in the skeletons of most patients. On arriving in bone tissue, disseminated tumour … Continue reading Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Patent: Burner Module & Integrated Gas Burner
A patent for a novel integrated gas/air burner module (Patent number: US2018320895A1), published by the United States Patent Office in 2018.
Chapter: Bone Mechanobiology in Health and Disease
This chapter describes the state-of-the-art in the study of bone mechanobiology, and was published in Mechanobiology in Health and Disease in 2018.
Chapter: Techniques to Study Mechanobiology
A chapter describing the multitude of methods which can be employed to answer mechanobiological research questions, published in Mechanobiology in Health and Disease in 2018.
Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors
A study of the link between fetal biomechanics and risk factors for DDH, published in the Journal of Biomechanics in 2018.
Stresses and strains on the human fetal skeleton during development
A study of how stress and strain change over gestation, published in the Journal of the Royal Society Interface in 2018.
Ontogeny of the human pelvis
A review of the development of the human pelvis in individuals, published in the Anatomical Record in 2017.
Function and failure of the fetal membrane
A study of the mechanics of fetal membrane rupture, published in the PLOS ONE in 2017.
In silico bone mechanobiology
A review of computational modelling in bone mechanobiology, published in the Wiley Interdisciplinary Reviews: Systems Biology & Medicine in 2016.
Mechanisms of osteocyte stimulation in osteoporosis
A study of osteocyte mechanical stimulation in osteoporosis, published in the Journal of the Mechanical Behaviour of Biomedical Materials in 2016.
Modeling the biomechanics of fetal movements
A study of the mechanics of fetal movements in utero, published in Biomechanics and Modeling in Mechanobiology in 2015.
Patent: Modified burner module
A patent for a gas/air burner module (Patent number: US20170122555A1), published by the United States Patent Office in 2015.
Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia
A study of the role of various mechanosensors in bone cell mechanosensation in vitro and in vivo, published in Biomechanics and Modeling in Mechanobiology in 2015.
Altered mechanical environment of bone cells in an animal model of short-and long-term osteoporosis
A study providing direct evidence of strain amplification in osteocytes in situ, alongside altered stimulation patterns in osteoporosis, published in the Biophysical Journal in 2015.
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
A study of the effects of location and orientation on the mechanical stimulation of osteocytes in vivo, published in the International Journal for Numerical Methods in Biomedical Engineering in 2013.
Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach
A study of the multi-physics environment of osteocytes, modelling both fluid shear and resulting strain stimulation, published in Biomechanics and Modeling in Mechanobiology in 2014.
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
A study demonstrating that the geometry of the osteocyte environment alone amplifies strain stimulation to the cell, published in the Journal of the Royal Society Interface in 2012.