A review of the broad sweep of organ-chip research in the cancer research in the UK, and the network of researchers and companies being developed, published in the journal Cancers in 2023 and available here.

A study combining transcriptomics (RNAseq) and computational modelling (CFD) to investigated the role played by aging and TGF-β in osteocyte mechanosensing, published in the Proceedings of the National Academy of Sciences (PNAS) in 2021 and available here. Abstract Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the mechanisms … Continue reading Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling

An organ-on-a-chip model of the how mechanical stimulation of osteocytes affects the phenotype of breast and prostate cancer cells, published in the journal Cancers 2021 and available here. Abstract Breast and prostate cancers preferentially metastasise to bone tissue, with metastatic lesions forming in the skeletons of most patients. On arriving in bone tissue, disseminated tumour … Continue reading Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype

A patent for a novel integrated gas/air burner module (Patent number: US2018320895A1), published by the United States Patent Office in 2018.

This chapter describes the state-of-the-art in the study of bone mechanobiology, and was published in Mechanobiology in Health and Disease in 2018.

A chapter describing the multitude of methods which can be employed to answer mechanobiological research questions, published in Mechanobiology in Health and Disease in 2018.

A study of the link between fetal biomechanics and risk factors for DDH, published in the Journal of Biomechanics in 2018.

A study of how stress and strain change over gestation, published in the Journal of the Royal Society Interface in 2018.

A review of the development of the human pelvis in individuals, published in the Anatomical Record in 2017.

A study of the mechanics of fetal membrane rupture, published in the PLOS ONE in 2017.

A review of computational modelling in bone mechanobiology, published in the Wiley Interdisciplinary Reviews: Systems Biology & Medicine in 2016.

A study of osteocyte mechanical stimulation in osteoporosis, published in the Journal of the Mechanical Behaviour of Biomedical Materials in 2016.

A study of the mechanics of fetal movements in utero, published in Biomechanics and Modeling in Mechanobiology in 2015.

A patent for a gas/air burner module (Patent number: US20170122555A1), published by the United States Patent Office in 2015.

A study of the role of various mechanosensors in bone cell mechanosensation in vitro and in vivo, published in Biomechanics and Modeling in Mechanobiology in 2015.

A study providing direct evidence of strain amplification in osteocytes in situ, alongside altered stimulation patterns in osteoporosis, published in the Biophysical Journal in 2015.

A study of the effects of location and orientation on the mechanical stimulation of osteocytes in vivo, published in the International Journal for Numerical Methods in Biomedical Engineering in 2013.

A study of the multi-physics environment of osteocytes, modelling both fluid shear and resulting strain stimulation, published in Biomechanics and Modeling in Mechanobiology in 2014.

A study demonstrating that the geometry of the osteocyte environment alone amplifies strain stimulation to the cell, published in the Journal of the Royal Society Interface in 2012.